With paddle over disc, a transdermal patch is placed either between a glass disc and an inert PTFE mesh, or directly onto a stainless steel mesh. This is placed at the bottom of the vessel, with the mesh facing upwards, under a rotating paddle. Transdermal testing is carried out at 32°C to reflect the temperature of the skin. Other variables such as the height setting and sampling requirements are the same as for USP Method 2.
Useful for
Transdermal Patches.
Advantages
Standard equipment (paddle) can be used, only adds a stainless steel disk assembly.
Standard Volume
900 ml.
Temperature
32°C.
Alternative
"Sandwich" / Watchglass.
USP 30 footnote:
“A suitable device is the watchglass-patch-polytef mesh sandwich assembly available as the transdermal Sandwich™”
Paddle Over Disc 33mm
Paddle Over Disc 65mm