With paddle over disc, a transdermal patch is placed either between a glass disc and an inert PTFE mesh, or directly onto a stainless steel mesh. This is placed at the bottom of the vessel, with the mesh facing upwards, under a rotating paddle. Transdermal testing is carried out at 32°C to reflect the temperature of the skin. Other variables such as the height setting and sampling requirements are the same as for USP
Useful forTransdermal patches
Standard volume900 ml
AdvantagesStandard equipment (paddle) can be used, only adds a stainless steel disk assembly.
Alternative"Sandwich" / Watchglass
USP 30 footnote:
“A suitable device is the watchglass-patch-polytef mesh sandwich assembly available as the transdermal Sandwich™”
Accepted by the FDA.